Derek Boerboom, DMV, Ph.D.

Training:

B.Sc. Biochemistry (McGill, 1993)

M.Sc. Biochemistry (McGill, 1995)

Ph.D. Molecular Biology (Montréal, 2000)

D.M.V. (Montréal, 2002)

Postdoctoral Sutdies : Molecular Endocrinologiy and Fonctional Genomic (Baylor College of Medicine, 2002-2005)

Professional Activities :

• Member of the Réseau Québécois en reproduction (RQR) and of the Centre de recherche en reproduction animale (CRRA)
• Research Chair of Canada in Molecular Biology and fonctional genomic of the ovary
• Editor of Biology of Reproduction and Endocrinology

Research Interest:  

• Study of the roles of Wnts in the reproductive system
• Etiology of granulosa tumor cells
• Animal modelization, transgenesis and fonctional genomic 

Lab members: 

• Alexandre Boyer, Research agent, This email address is being protected from spambots. You need JavaScript enabled to view it.
• Evelyne Lapointe, PhD, This email address is being protected from spambots. You need JavaScript enabled to view it.
• Meggie Girard, Technician, This email address is being protected from spambots. You need JavaScript enabled to view it.
• Mayra Tsoi, DMV-Ms.C. student, This email address is being protected from spambots. You need JavaScript enabled to view it.
• Charlène Rico, Postdoctorat, This email address is being protected from spambots. You need JavaScript enabled to view it.

Liste de publications (since 2006): 

1- Laguë, M.N., Detmar, J., Paquet, M., Boyer, A., Richards, J.S., Adamson, S.L., and Boerboom, D.  Decidual PTEN expression is required for trophoblast invasion in the mouse. American Journal of Physiology: Endocrinology & Metabolism In press (2010).

2- Lapointe, E. and Boerboom, D.  WNT signaling and the regulation of ovarian steroidogenesis.  Frontiers in Bioscience In press (2010).

3- Brown, H.M., Dunning, K.R., Robker, R.L., Boerboom, D., Pritchard, M., Lane, M., and Russell, D.L. Adamts1 cleavage of versican mediates essential structural remodelling of the ovarian follicle and cumulus-oocyte matrix during ovulation.  Biology of Reproduction In press (2010).

4- Boyer, A., Lapointe, E., Zheng, X., Cowan, R.G., Paquet, M., Quirk, S.M., DeMayo, F.J., Richards, J.S., and Boerboom, D.  WNT4 is required for ovarian follicle development.  The FASEB Journal Aug;24(8):3010-25 (2010).

5- Buczinski, S., Rezakhani, A. and Boerboom, D. Heart disease in cattle: a review of the current data regarding diagnosis, therapeutic approaches and prognosis.  The Veterinary Journal Jun;184(3):258-63 (2010).

6- Boyer, A., Goff, A.K., and Boerboom, D. WNT signaling in ovarian follicle biology and tumorigenesis.  Trends in Endocrinology and Metabolism Jan;21(1):25-32 (2010).

7- Nadeau, M.E., Kaartinen, M.J., Lague, M.N., Paquet, M., Huneault, L.M., and Boerboom, D.  Development of a mouse surgical model for metastatic ovarian granulosa cell tumor.  Comparative Medicine Dec;59(6):553-6 (2009).

8- Zheng, X.F., Boerboom, D. and Carrière, P.D. Transforming growth factor-β1 maintains estrogenic capacity, inhibits luteinization and promotes apoptosis in bovine granulosa cells.  Reproduction Jun;137(6):969-77 (2009).

9-  Boyer, A., Paquet, M., Laguë, M.N., Hermo, L. and Boerboom, D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.  Carcinogenesis May;30(5):869–878 (2009).

10- Laguë, M.N., Paquet, M., Chu, S., Kaartinen, M.J., Jamin, S.P., Behringer, R.R., Fuller, P.J., Mitchell, A., Doré, M., Huneault, L.M., Richards, J.S. and Boerboom, D. Synergistic effects of PTEN loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis Nov;29(11):2062-72 (2008).

11- Boyer, A., Hermo, L., Paquet, M., Robaire, B. and Boerboom, D. Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in Sertoli cells.  Biology of Reproduction Sep;79(3):475-85 (2008).

12- Paquet M., Penney, J. and Boerboom, D. Lateral femoral hernias in a line of FVB/NHsd mice: a new confounding lesion linked to genetic background?  Comparative Medicine Aug;58(4):395-8 (2008).

13-  Brown, K.A., Boerboom, D., Bouchard, N., Doré, M., Lussier. J.G. and Sirois, J.  Human chorionic gonadotropin-dependent induction of an aldo-keto reductase (AKR1C23) with 20-alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo.  The Journal of Molecular Endocrinology Jun;36(3):449-61 (2006).

14-  Boerboom, D., White, L., Dalle, S., Courty, J. and Richards, J.S.  Dominant-stable b-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Cancer Research Feb 15;66(4):1964-73 (2006). 

Current subventions: