Jean Sirois, DMV, MSc, PhD
Université de Montréal
Département de biomédecine vétérinaire
3200, Sicotte Street
Saint-Hyacinthe, Québec
J2S 7C6
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Phone: 450 773-8521, poste 8542
Fax: 450 778-8103


University training:


DMV (Montréal, 1983)MSc (Montréal, 1987)
PhD (Cornell University, Ithaca, New York, 1990)
Postdoctoral training (Baylor College of Medicine, Houston, Texas, 1990-1993)


Research interests:


  • Développement folliculaire ovarien et ovulation
  • Biosynthèse et action des prostanoïdes
  • Stéroïdogénèse


Recent publications:


Sayasith K, Sirois J. 2014. Expression and regulation of stromal cell-derived factor-1 (SDF-1) and chemokine CXC motif receptor 4 (CSCR4) in equine and bovine preovulatory follicles. Mol Cell Endocrinol 391:10-21.


Sayasith K, Lussier J, Doré M, Sirois J. 2013. Human chorionic gonadotropin-dependant up-regulation of epiregulin and amphiregulin in equine and bovine follicles during the ovulatory process. Gen Comp Endocrinol 180:39-47.


Sayasith K, Lussier J, Sirois J. 2013. Expression, regulation and promoter activation of vanin-2 (VNN2) in bovine follicles prior to ovulation. Biol. Reprod 89:98,1-11.


Sayasith K, Lussier J, Sirois J. 2013. Molecular characterization and transcriptional regulation of a disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) in bovine preovulatory follicles. Endocrinology 154:2857-2869.


Most cited manuscrits:


Sirois J, Doré M. 1997. The late induction of prostaglandin G/H synthase-2 in equine preovulatory follicles supports its role as a determinant of the ovulatory process. Endocrinology 138:4427-4434. (106 citations)


Sirois J. 1994. Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo. Endocrinology 135:841-848. (148 citations)


Sirois J, Richards JS. 1993. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells: Evidence for the role of a cis-acting C/EBP beta promoter element. J Biol Chem 268:21931-21938. (202 citations)


Sirois J, Levy LO, Simmons DL, Richards JS. 1993. Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein binding regions. J Biol Chem 268 :12199-12206. (174 citations)


Sirois J, Simmons DL, Richards JS. 1992. Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro. J Biol Chem 267 :11586-11592. (219 citations)


Sirois J, Richards JS. 1992. Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. . J Biol Chem 267 :6382-6388. (280 citations)


Sirois J, Fortune JE. 1990. Lengthening the bovine estrous cycle with low levels of exogenous progesterone : a model for studying ovarian follicular dominance. Endocrinology 127 :916-925. (278 citations)


Sirois J, Fortune JE. 1990. Ovarian follicular dynamics during the estrous cycle in heifers monitored by real-time ultrasonography. Biol Reprod 39 :308-317. (553 citations)