Derek Boerboom

Derek Boerboom, DMV, Ph.D.

Associate ProfessorDBoerboom

Université de Montréal

Département de biomédecine vétérinaire

3200 Sicotte

St-Hyacinthe, Qc

J2S 2M2

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Phone: 450 773-8521 ext. 0160

Fax: 450-778-8103

Formation universitaire :

B.Sc. Biochimie (McGill, 1993)

M.Sc. Biochimie (McGill, 1995)

Ph.D. Biologie moléculaire (Montréal, 2000)

D.M.V. (Montréal, 2002)

Études postdoctorales : Endocrinologie moléculaire et génomique fonctionnelle (Baylor College of Medicine, 2002-2005)

Activités professionnelles :

  • Membre du Réseau Québécois en Reproduction (RQR) et du Centre de Recherche en Reproduction Animale (CRRA)
  • Chaire de Recherche du Canada en Biologie Moléculaire et Génomique Fonctionnelle de l'Ovaire
  • Rédacteur aux revues Endocrinology et Biology of Reproduction

 

Intérêts de recherche:  

  • Étude des rôles des Wnts dans le système reproducteur
  • Les cancers du système reproducteur
  • Modélisation animale, trangénèse et génomique fonctionnelle 

 

Membres du Laboratoire, position et adresses courriel:

Nom

Position

Adresse courriel

Charlène Rico

Postdoc

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Gustavo Zamberlam

Postdoc

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Atefeh Abedini

PhD candidate

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Sabin Filimon

DMV-MSc candidate

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Meggie Girard

Technician

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Liste de publications (depuis 2008):

  1. Dong,Y., Wu, H., Pasula, S., Liu, X., Cai, X., Tessneer, K.L., Yu, L., Chang, B., Hahn, S., McManus, J., Song, K., Silasi-Mansat, R., Saunders, D., Njoku, C., Mehta-D’Souza, P., Zhu, H., Chen, Y., Towner, R., Lupu, F., Srinivasan, R.S., McEver, R.P., Xia, L., Boerboom, D. and Chen, H. Inhibition of tumor growth and metastasis by a potent epsin UIM mimetic. Science Translational Medicine (Submitted, 2014).
  2. Abedini, A., Zamberlam G., Boerboom, D. and Price, C.A. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Molecular and Cellular Endocrinology (Submitted, 2014).
  3. Nadeau, M.E., Rico, C., Tsoi, M., Vivancos, M., Filimon, S., Paquet, M. and Boerboom, D. Pharmacological targeting of valosin containing protein (VCP) selectively kills canine lymphoma cells by inducing DNA damage. BMC Cancer (Submitted, 2014).
  4. Boerboom, D., Kumar, V., Boyer, A., Lambrot, R., Zhou, X., Wang, Y., Rico, C., Boehm, U., Paquet, M., Céleste, C., Kimmins, S., and Bernard, D.J. β-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo. Endocrinology (In Press, 2014).
  5. Rico, C., Dodelet-Devillers, A., Paquet, M., Tsoi, M., Lapointe, E., Carmeliet, P. and Boerboom, D. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival. Biology of Reproduction Jun;90(6):135 (2014).
  6. Tsoi, M., Laguë, M.N., Boyer, A., Paquet, M., Nadeau, M.E. and Boerboom, D. Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor. Translational Oncology Jun 1;6(3):226-233 (2013).
  7. Fortin, J., Kumar, V., Zhou, X., Auwerx, J., Schoonjans, K., Boerboom, D. and Bernard, D.J. NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.PLoS One 8(3):e59058 (2013).
  8. Tran, S., Zhou, X., Lafleur, C., Kimmins, S., Boehm, U., Treier, M., Boerboom, D. and Bernard, D.J. Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Molecular Endocrinology Mar;27(3):407-421(2013).
  9. Lapointe, E., Boyer, A., Rico, C., Paquet, M., Franco, H., Gossen, J., DeMayo, F.J., Richards, J.S. and Boerboom, D. FZD1 Regulates cumulus expansion genes and is required for normal female fertility. Biology of Reproduction Nov 1;87(5):104 (2012).
  10. Rico, C., Lagüe, M.N., Lefèvre, P., Dodelet-Devillers, A., Kumar, V., Paquet, M., Nadeau. M.E.and Boerboom, D. Pharmacological targeting of mammalian target of rapamycin (mTOR) inhibits ovarian granulosa cell tumor growth.Carcinogenesis Nov;33(11):2283-92 (2012).
  11. Laguë, M.N., Romieu-Mourez, R., Bonneil, E., Boyer, A., Pouletty, N., Mes-Masson, A.M., Thibault, P., Nadeau, M.E. and Boerboom, D. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers.PLoS One 7(8):e42470 (2012).
  12. Richards, J.S., Fan, H.Y., Liu, Z., Tsoi, M., Laguë, M.N., Boyer, A. and Boerboom, D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis. Oncogene Mar 22;31(12):1504-20 (2012).
  13. Boyer, A., Yeh, J.R., Zhang, X., Paquet, M., Gaudin, A., Nagano, M.C. and Boerboom, D. Sustained CTNNB1 signaling in Sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One 7(1):e29764 (2012).
  14. Deschesne, K., Céleste, C., Boerboom, D. and Theoret, C.L. Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. Journal of Dermatological Science Jan;65(1):12-8 (2012).
  15. Paquet, M., El-Warrak, A.O., Laguë, M.N. and Boerboom, D. Atypical caudal duplication with pseudohermaphroditism in a dog. Journal of Veterinary Diagnostic Investigation Sep;23(5):1037-40 (2011).
  16. Boerboom, D., Lafond, J.F., Zheng, X., Lapointe, E., Mittaz, L., Boyer, A., Pritchard, M.A., DeMayo, F.J., Mort, J.S, Drolet, R. and Richards, J.S. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Developmental Dynamics Jul;240(7):1806-14 (2011).
  17. Franco, H.L., Dai, D., Lee, K.Y., Rubel, C.A., Roop, D., Tsai, S.Y., Boerboom, D., Lydon, J.P., Jeong, J.W., Bagchi, I.C., Bagchi, M.K. and DeMayo, F.J. WNT4 is a key regulator of proper postnatal uterine development and progesterone signaling during embryo implantation and decidualization. The FASEB Journal Apr;25(4):1176-87 (2011).
  18. Deschesne, K., Céleste, C., Boerboom, D. and Theoret, C.L. Constitutive expression of HIF-1α in keratinocytes during the repair of skin wounds in horses. Wound Repair and Regeneration Mar;19(2):250-9 (2011).
  19. Lapointe, E. and Boerboom, D. WNT signaling and the regulation of ovarian steroidogenesis. Frontiers in Bioscience Jan;S3(1):276-85 (2011).
  20. Laguë, M.N., Detmar, J., Paquet, M., Boyer, A., Richards, J.S., Adamson, S.L. and Boerboom, D. Decidual PTEN expression is required for trophoblast invasion in the mouse. American Journal of Physiology: Endocrinology & Metabolism Dec;299(6):E936-46 (2010).
  21. Brown, H.M., Dunning, K.R., Robker, R.L., Boerboom, D., Pritchard, M., Lane, M., and Russell, D.L. Adamts1 cleavage of versican mediates essential structural remodelling of the ovarian follicle and cumulus-oocyte matrix during ovulation. Biology of Reproduction Oct;83(4):549-57 (2010).
  22. Boyer, A., Lapointe, E., Zheng, X., Cowan, R.G., Paquet, M., Quirk, S.M., DeMayo, F.J., Richards, J.S., and Boerboom, D. WNT4 is required for normal ovarian follicle development and female fertility. The FASEB Journal Aug;24(8):3010-25 (2010).
  23. Buczinski, S., Rezakhani, A. and Boerboom, D. Heart disease in cattle: a review of the current data regarding diagnosis, therapeutic approaches and prognosis. The Veterinary Journal Jun;184(3):258-63 (2010).
  24. Boyer, A., Goff, A.K., and Boerboom, D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends in Endocrinology and Metabolism Jan;21(1):25-32 (2010).

Prix et distinctions:

2011: SSR New Investigator Award

Subventions courantes:

04/14-03/19

Canadian Institutes of Health ResearchOperating grants
Bernard, Daniel (PI); Boerboom, Derek (Co-applicant)
Project Title : Transcriptional regulation of follicle stimulating hormone synthesis

09/13 - 08/15

Cancer Research Society
Operating Grant
Boerboom, Derek (PI); Mes-Masson, Anne-Marie (Co-Investigator)
Project Title: Assessment of VCP as a potential diagnostic marker for early-stage and recurrent ovarian cancer
120000$

09/13 - 08/15

Morris Animal Foundation
First Award
Nadeau, Marie-Ève (PI); Boerboom, Derek (Co-Investigator)
Project Title: Valosin containing protein (VCP): a novel therapeutic target for canine lymphoma
64908$ (US)

05/13 - 04/16

Le Fonds Québecois de la Recherche sur la nature et les technologies
Projet de Recherche en Équipe
Bernard, Daniel (Leader); Boerboom, Derek and Hébert, Terence (Co-applicants);
Project Title: Importance fonctionnelle d'une divergence évolutive de la structure du récepteur de la gonadolibérine chez les mammifères
135000$
 
05/13 - 04/14
      
Faculté de Médecine Vétérinaire, Université de Montréal
Fonds en santé des animaux de compagnie (FSAC)                                
Nadeau, Marie-Ève (PI); Boerboom, Derek (Co-applicant)
Project title: VCP (Valosin containing protein) : une cible thérapeutique d'intérêt pour le traitement de l'ostéosarcome et du lymphome canin
10000$
 
04/13 - 03/18
      
Canadian Institutes of Health Research
Operating grants
Boerboom, Derek (PI); Clarke, Hugh (Co-applicant)
Project Title: Elucidation of the roles of Wnt signaling in the mammalian ovary
660590$
 
10/12 - 09/15
     
Canadian Institutes of Health Research
Operating grants
Bernard, Daniel (PI); Boerboom, Derek (Co-applicant)
Project Title: Mechanisms of GnRH action
445056$
 
04/12 - 03/17
  
National Science and Engineering Research Council
Discovery grants
Boerboom, Derek (PI)
Project title: Role of development signaling pathways in testicular physiology and spermatogenesis
135000$
 
06/11 - 05/16
   
Canada Research Chairs
Canada Research Chair (Tier II)
Boerboom, Derek (PI)
Project Title: Canada Research Chair in ovarian molecular biology and functional genomics (renewal)
500000$
 
05/11 - 04/14
 
Le Fonds Québecois de la Recherche sur la nature et les technologies
Projet de Recherche en Équipe
Price, Christopher (Leader); Boerboom, Derek and Richard, François (Co-applicants);
Project Title: Nouvelles voies vers l'embryon sain chez les animaux de consommation
123750$