Francis Beaudry

Professeur agrégé (coordonnées)

Formation universitaire

  • B.Sc. chimie (Sherbrooke, 1993)
  • Ph.D. chimie analytique et médicinale (Anglia Ruskin, Cambridge (UK), 2007)

Activités professionnelles

  • Chercheur membre du Groupe de recherche en pharmacologie animale du Québec (GREPAQ)
  • Chercheur membre de Pharmaqam
  • Chercheur Membre du Réseau québécois en recherche sur les médicaments (RQRM
  • Chercheur membre du Réseau québécois de recherche sur la douleur (RQRD)

Intérêts professionnels / domaines de recherche (voir site web)

  • Spectrométrie de masse (HPLC-MS/MS, MALDI-TOF)
  • Protéomique, peptidomique et métabolomique
  • Chimie médicinale
  • Pharmacocinétique et métabolisme
  • Pharmacologie de la douleur

Publications 2009-2014

Rechercher cet auteur dans Pubmed

R. Santamaria, F. Pailleux and F. Beaudry (2014), In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry, Biomedical Chromatography, DOI 10.1002/bmc.3199

F. Pailleux and F. Beaudry (2014), Evaluation of Multiple Reaction Monitoring Cubed for the Analysis of Tachykinin Related Peptides in Rat Spinal Cord using a Hybrid Triple Quadrupole–Linear Ion Trap Mass Spectrometer, Journal of Chromatography B. 947-948:164-167

P. Rialland, C. Otis, M.L. de Courval, P-Y. Mulon, D. Harvey, S. Bichot, D. Gauvin, A. Livingston, F. Beaudry, D. Frank, J.R.E. del Castillo, E. Troncy (2014), Assessing experimental visceral pain in dairy cattle: a pilot, prospective, blinded, randomized and controlled study focusing on spinal pain proteomics, Journal of Dairy Science, doi: 10.3168/jds.2013-7142. [Epub ahead of print]

ML. Gauthier, F. Beaudry and P. Vachon (2013), Intrathecal [6]-Gingerol Administration Alleviates Peripherally-induced Neuropathic Pain in Male Sprague-Dawley Rats, Phytotherapy Research, DOI: 10.1002/ptr.4837. 

F. Pailleux, P. Vachon, J. Lemoine and F. Beaudry (2013), Targeted Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry Analysis of Tackykinin Related Peptides Reveals Significant Expression Differences in a Rat Model of Neuropathic Pain, Neuropeptides, 47(4):261-271 

D. St-Germain Lavoie, P. Pailleux, P. Vachon and F. Beaudry (2013), Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry, Biomedical Chromatography, 27: 882–888

F. Pailleux, J. Lemoine, F. Beaudry (2013) Investigation of the Metabolic Biotransformation of Substance P in Liver Microsomes by Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry, Biomedical Chromatography, 27:39-47

A. Castel, P. Hélie, F. Beaudry and P. Vachon (2013), Bilateral central pain sensitization in rats following a unilateral thalamic lesion can be treated with high doses of ketamine, BMC Veterinary Research, 9:59.

P. Vachon, M. Millecamps, L. A. Low, S. J. Thompson, F. Pailleux, F. Beaudry, M. Catherine Bushnell, and L.S. Stone (2013), Reversal of chronic neuropathic pain by environmental enrichment in mice, Behavioral and Brain Functions, 9:22 (www.behavioralandbrainfunctions.com/content/9/1/22)

D. Veilleux-Lemieux, A. Castel, D. Carrier, F.Beaudry  and P. Vachon (2013), Comparative pharmacokinetics of ketamine and xylazine in young and old Sprague Dawley rats, Journal of the American Association for Laboratory Animal Science, manuscript ID: JAALAS-12-000160.

M. Rhouma, A. de Oliveira El Warrak, E. Troncy, F. Beaudry, Y. Chorfi (2013) Anti-inflammatory response of dietary vitamin E during early stages of surgically-induced osteoarthritis in dogs and its consequences on pain and joint structures, Canadian Journal of Veterinary Research, 77(3): 191-198. 

P. Rialland, S. Bichot, B. Lussier, M. Moreau, F. Beaudry, JRE del Castillo, D. Gauvin, E. Troncy (2013), Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis, The Canadian Journal of Veterinary Research, 77(1):66-74.

F. Pailleux, F. Beaudry (2012), Internal Standard Strategies for Relative and Absolute Quantitation of Peptides in Biological Matrices by Liquid Chromatography Tandem Mass Spectrometry. Biomedical Chromatography, 26(8):881-891 

F. Pailleux, J. Lemoine, F. Beaudry (2012), Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance P and neurokinin A expression in the central nervous system, Neurochemical Research, 37(12) 2678-2685 

K. D. Bao, A. Letellier and F. Beaudry (2012), Analysis of Staphylococcus Enterotoxin B using Differential Isotopic Tags and Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry, Biomedical Chromatography, 26:1049–1057 

D. Veilleux-Lemieux, F. Beaudry, P. Hélie and P. Vachon (2012), Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats, Veterinary Medicine: Research and Reports, 3:99–109.

V.L. Robert, F. Beaudry and P. Vachon (2012), Evaluation of physiological changes in Xenopus laevis frogs and pharmacological parameters of MS-222 following an immersion bath at anesthetic doses, Journal of the American Association for Laboratory Animal Science, 51(4):464-468.

C.E. Ferland, F. Beaudry and P. Vachon (2012) Antinociceptive effects of eugenol in a monoiodoacetate-induced osteoarthritis rat model. Phytotherapy Research, 26: 1278–1285.

C.E. Ferland, F. Pailleux, P. Vachon and F. Beaudry (2011), Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry, Neuropeptides, 45(6):423-429.

ML Gauthier, J. Douat, P. Vachon and F. Beaudry (2011), Characterization of [6]-Gingerol Metabolism in Rat by Liquid Chromatography Electrospray Tandem Mass Spectrometry, Biomedical Chromatography, 25(10):1150-1158 

C.E. Ferland, S. Laverty, F. Beaudry and P. Vachon (2011), Gait Analysis and Pain Response of Two Rodent Models of Osteoarthritis, Pharmacology Biochemistry and Behavior, 97(3):603-610.

J. Douat, P. Vachon and F. Beaudry (2011), In Vitro Metabolism of Capsazepine, a Vanilloid Transient Receptor Potential  Channel Antagonist, by Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry, Biomedical Chromatography, 25(4):479-492 

F. Beaudry (2010), Stability comparison between sample preparation procedures for mass spectrometry-based targeted or shotgun peptidomic analysis, Analytical Biochemistry, 407:290-292.

F. Beaudry, A. Ross, P.P. Lema and P. Vachon (2010), Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in rat model of neuropathic pain. Phytotherapy Research, 24(4):525-530.
L. Lionnet, F. Beaudry and P. Vachon (2010), Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats, Phytotherapy Research, 24:1645-1653.

M.C. Duhamel, E. Troncy and F. Beaudry (2010), Metabolic Stability and Determination of Cytochrome P450 Isoenzymes Contribution to the Metabolism of Medetomidine in Dog Liver Microsomes, Biomedical Chromatography, 24(8):868-877 

M.J. Kaartinen, D. Pang, M. Moreau, O. Vainio, F. Beaudry, JRE del Castillo, L.A. Lamont, S.G. Cuvelliez and E. Troncy (2010), Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs, Veterinary Therapeutics, 11(1);E1-E16.

F. Beaudry, C. Ferland-Legault and P. Vachon (2009), Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray ion trap mass spectrometry. Biomedical Chromatography, 23(9):940-950.

J-P. Roy, L. DesCôteaux, D. DuTremblay, F. Beaudry  and J. Elsener (2009), Efficacy of a 5-day extended lactation therapy with cephapirin sodium (Cefa-Lak®) in dairy cows chronically infected with Staphylococcus aureus. The Canadian Veterinary Journal, 50:1257-1262.

F. Beaudry, R.B. Moore (2009), Design of New Electrode Interface to Improve Transport of Atmospheric Pressure Ions Into a Mass Spectrometer. e-Journal of Chemistry. 6(1):39-46.

F. Beaudry, P. Vachon (2009), Quantitative Determination of Capsaicin, a Transient Receptor Potential Channel Vanilloid 1 Agonist, by Liquid Chromatography Quadrupole Ion Trap Mass Spectrometry: Evaluation of in vitro Metabolic Stability, Biomedical Chromatography. 23:204-211.

M. Meulyzer, P. Vachon, F. Beaudry, T. Vinardell, H. Richard, G. Beauchamp, S. Laverty (2009), Joint Inflammation Increases Glucosamine Levels Attained in Synovial Fluid Following Oral Administration of Glucosamine Hydrochloride. Osteoarthritis and Cartilage, 17(2):228-234.

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