Pascal Vachon

Professeur titulaire (coordonnées)
Sciences et médecine des animaux de laboratoire

Formation universitaire

  • B.Sc. kinésiologie (Waterloo, 1982)
  • M.Sc. kinanthropologie (Sherbrooke, 1984)
  • Ph.D. Sciences neurologiques (Montréal, 1991)

  • D.M.V. (Montréal, 1992)
  • Études postdoctorales
    1. Mécamismes de l'épilepsie (Montréal, 1992)
    2. Xénotransplantation du médulloblastome humain chez les souris et traitements au facteur de croissance fibroblastique, (Hôpital Ste-Justine, Université de Montréal, 1992-94)
  • Diplômé de l'American College of Laboratory Animal Medicine (2003)

Activités professionnelles

  • Consultation en médecine des animaux de laboratoire (AAALAC ad hoc consultant)

Intérêts professionnels / domaines de recherche

  • Étude de la pathologie et des traitements du trauma crânien.
  • Pharmacologie et physiologie de l'anesthésie des animaux de laboratoire (amphibiens, poissons et rongeurs)
  • Études des neuropeptides reliés à la douleur neuropathique utilisant un modèle murin et pharmacocinétique des drogues pour le traitement de cette condition

Publications récentes sélectionnées

Castel A, Vachon P. Gabapentin reverses central pain sensitization following a collagenase-induced intrathalamic hemorrhage in rats. J Pain Res 7: 5-12, 2014.

Vachon P, Millecamps M, Low L, Pailleux F, Beaudry F, Thompson S, Bushnell MC, Stone L . Alleviation of chronic neuropathic pain in mice by environmental enrichment well after the establishment of chronic pain. Behav Brain Funct 9:22, 2013

Veilleux-Lemieux D, Castel A, Carrier D, Beaudry F, Vachon P. Comparative pharmacokinetics of ketamine and xylazine in young and old Sprague Dawley rats. J Am Assoc Lab Anim Sci 52: 567-570, 2013.

Castel A, Hélie P, Beaudry F, Vachon P. Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine. BMC Vet Res 9: 59, 2013.

Prefontaine L, Carrier D, Lesperance S, Pellerin V, Vachon P. Méthodes d’élimination d’Helicobacter spp des colonies de souris d’élevage d’un centre de recherche hospitalier. Sci Tech Anim Lab 39 (3): 15-20, 2013.

Gauthier ML, Beaudry F, Vachon P. Intrathecal 6-gingerol alleviates peripherally-induced neuropathic pain in male Sprague-Dawley rats. Phytotherap Res 27: 1251-1254, 2013.

Pailleux F, Vachon P, Lemoine J, Beaudry F. Targeted liquid chromatography quadrupole ion trap mass spectrometry analysis of tackykinin related peptides reveals significant expression differences in a rat model of neuropathic pain.
Neuropeptides 47: 261-271, 2013.

St-Germain-Lavoie D, Pailleux F, Vachon P, Beaudry F. Characterization of xylazine in vitro metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole linear ion trap mass spectrometry.
Biomed Chromatogr  27: 882-888, 2013.

Guénette SA, Giroux MC, Vachon P. Pain perception and anesthesia in research frogs. Exp Anim 62:87-92,2013.

Tajerian M, Alvarado S, Millecamps S, Vachon P, Crosby C, Bushnell MC, Szyf M, Stone LS. Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. Plos One  8 (1): e55259, 2013.

Veilleux-Lemieux D, Beaudry F, Hélie P, Vachon P. Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague-Dawley rats. Vet Med Res Reports 3: 99-109, 2012.

Lalonde-Robert V, Desgent S, Duss S, Vachon P. Electroencephalographic and physiologic changes during tricaine methanesulfonate euthanasia in Xenopus leavis frogs. J Am Assoc Lab Anim Sci 51: 622-627, 2012.

Ferland-Legault CE, Laverty S, Beaudry F, Vachon P. Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model. Phytotherap Res 26: 1278-1285,  2012.

Lalonde-Robert V, Beaudry F, Vachon P. Pharmacological parameters and physiologic changes in frogs (Xenopus laevis) after immersion at anesthetic doses. J Am Assoc Lab Anim Sci 51: 464-468, , 2012

Roy G, Orlando H, Lema PP, Vachon P. Central pain following a collagenase-induced hematoma in the basal ganglia and thalamus can be reversed with gabapentin. Scand J Lab Anim Sci, 38: 157-165, 2011.

Ferland-Legault C, Laverty S, Beaudry F, Vachon P. Gait analysis and pain response of two rodent models of osteoarthritis. Pharmacol Biochem Behav 97:603-610, 2011.

Ferland-Legault CE, Pailleux F, Vachon P, Beaudry F. Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry. Neuropeptides 45: 423-429, 2011.

Goulet F, Vachon P, Hélie P. Evaluation of the toxicity of eugenol at anesthetic doses in African Clawed frogs (Xenopus leavis). Tox Path 39: 471-477, 2011.

Lionnet L, Beaudry F, Vachon P. Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats. Phytotherap Res  24: 1645-1653, 2010.

Serantepe V, Lema P, Didri L, Hadj SB, Caqueret A, Carpentier S, Boucher F, Levade T, Carman L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud J, Morales CR, Pshezhetsky AV. Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.  PLoS Genet 6: 1-13,  2010.

Goulet F, Hélie P,Vachon P. Eugenol anesthesia of Xenopus leavis frogs of different body weight. J Am Assoc Lab Anim Sci 49: 460-463, 2010.

Beaudry F, Ross A, Lema PP, Vachon P. Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain. J Phytotherap 24: 525-530, 2010

Savard C, Lema PP, Hélie P, Vachon P. Evaluation of delayed dexamethasone treatment on the outcome of collagenase-induced intracerebral hemorrhage in rats. Comp Med 59: 444-448, 2009.

Beaudry F, Catherine Ferland-Legault, Vachon P. Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry. Biomed Chromatograph 23:940-950, 2009.

Meulyzer M, Vachon P, Beaudry F, Vinardell E, Richard H, Beauchamp G, Laverty S. Joint inflammation increases glucosamine levels attained in synovial fluid following of oral administration of glucosamine hydrochloride when compared to healthy joints. Osteoarthritis Cartilage 17: 228-234, 2009.

Beaudry F, Vachon P. Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 (TRPV1) agonist, by liquid chromatography quadrupole ion trap mass spectrometry. Biomed Chromatograph 23:204-211, 2009.

Ravenelle F, Vachon P, Rigby-Jones AE, Sneyd JR, Le Garrec D, Gori S, Lessard D, Smith DC. Anesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation. Br J Anaesth 101 (2): 186-193, 2008.

Guénette SA, Beaudry F, Vachon P. Anesthetic properties of propofol in African clawed frogs (Xenopus leavis). J Am Assoc Lab Anim Sci 47 (5) : 35-38, 2008.

Newby N, Robinson R, Vachon P, Beaudry F, Stevens ED. Pharmacokinetics and metabolism of morphine in freshwater rainbow trout (Onchorynchus mykiss). J Vet Pharmacol Therap 31:117-127, 2008

Meulyzer M, Vachon P, Beaudry F, Vinardell E, Richard H, Beauchamp G, Laverty S. Comparison of pharmacokinetics and synovial fluids levels following administration of glucosamine sulphate and hydrochloride. Osteoarthritis Cartilage 16: 973-979, 2008.

Beaudry F, Vachon P, Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry. Biomed Chromatogr 22:1-4, 2008.

Guénette SA, Marier JF, Beaudry F, Vachon P. Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats . Eur J Pharmacol 562 : 60-67, 2007.

Guénette S, Hélie P, Beaudry F, Vachon P. Eugenol for anesthesia of Xenopus leavis frogs. Vet Anesth Analg 34 (3) 164-170, 2007.

Guénette SA, Beaudry F, Hélie P, Uhland C, Vachon P. Pharmacokinetics of eugenol in rainbow trout (Onchorhynchus mykiss). Aquaculture 266 : 262-265, 2007.

Ferland C, Veilleux-Lemieux D, Vachon P. Effects of buprenorphine on an induced intracerebral hematoma rat model. J Am Assoc Lab Anim Sci 46 (2) 13-16, 2007.

Beaudry F, Girard C, Vachon P. Early dexamethasone treatment following sciatic nerve cuff implantation decreases substance P in lumbar spinal cord of rats with neuropathic pain. Can J Vet Res 71(2) 90-97, 2007.

Beaudry F, Ross A, Vachon P. Development of a LC-ESI/MS/MS assay for the quantification of vanillin using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity. Biomed Chromatogr 21 (2) 113-115, 2007.

Guénette SA, Marier JF, Beaudry F, Vachon P. Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats.   J Vet Pharmacol Therap 29: 265-270, 2006.

Beaudry F, Guénette SA, Vachon P. Determination of eugenol in rat plasma by LC-ESI/MS/MS simple a simple off-line dansyl chloride derivatization reaction to enhance signal activity. Biomed Chromatogr, 1216-1222, 2006.

Ross A, Guénette SA, Hélie P, Vachon P. Cas de nécrose cutanée chez les grenouilles africaines à griffes Xenopus leavis. Can Vet J 47 2006.

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