John Morris Fairbrother

Professeur titulaire (coordonnées)

Formation universitaire

  • Baccalauréat en médecine vétérinaire (B.V.Sc., University of Sydney, Australie, 1972)
  • Doctorat en médecine vétérinaire, option microbiologie vétérinaire (Ph.D., Cornell University, New York, 1985)

Activités professionnelles

Intérêts professionnels / domaines de recherche

  • Surveillance des E. coli pathogènes chez les animaux et zoonotiques
  • Influence des facteurs environnementaux sur les gènes de virulence et de résistance antimicrobienne d’E. coli dans l’écosystème intestinal de différentes espèces animales
  • Identification de nouvelles adhésines fimbriaires
  • Caractérisation du mécanisme d'attachement et d'effacement des E. coli d'origine animale
  • Étude de la pathogénicité des E. coli
  • Identification de facteurs de virulence d'E. coli causant la diarrhée post-sevrage chez le porc
  • Vaccination et autres stratégies de prévention de la diarrhée post-sevrage associée à E. coli chez les animaux de production
  • Diagnostic des E. coli

Principales publications

Avec comité de lecture

Smith MG, Jordan D, Chapman TA, Chin JJ-C, Barton MD, Do TN, Fahy VA, Fairbrother JM, Trott DJ (2010). Antimicrobial resistance and virulence gene profiles in multi-drug resistant enterotoxigenic Escherichia coli isolated from pigs with post-weaning diarrhoea. Veterinary Microbiology. Sous presse.

Lefebvre B, Diarra MS, Fairbrother JM, Nadeau E, Dubois MJr, Malouin F (2010). Intestinal Mucosa Adherence and Cytotoxicity of A Sorbitol-Fermenting, Shiga Toxin-Negative Escherichia coli O157 Isolate With an Atypical Type III Secretion System. Foodborne Pathogens and Disease 7: 985-990.

Bruant G, Zhang Y, Garneau P, Wong J, Laing C, Fairbrother JM, Gannon VPJ, Harel J (2009). Two distinct groups of porcine enteropathogenic Escherichia coli strains of serogroup O45 are revealed by comparative genomic hybridization and virulence gene microarray. BMC Genomics 10: 402.

Lessard M, Dupuis M, Gagnon N, Nadeau E, Matte JJ, Goulet J, Fairbrother JM (2009). Administration of Pediococcus acidilactici or Saccharomyces cerevisiae boulardii modulates development of porcine mucosal immunity and reduces intestinal bacterial translocation after Escherichia coli challenge. Journal of Animal Science 87: 922-934.

Calinescu C, Nadeau E, Mulhbacher J, Fairbrother JM, Mateescu MA (2007). Carboxymethyl high amylose starch for F4 fimbriae gastro-resistant oral formulation. International Journal of Pharmaceutics 343: 18-25.

Lévesque S, Martinez G and Fairbrother JM (2007). Improvement of adjuvant systems to obtain a cost-effective production of high levels of specific IgY. Poultry Science 86: 630-635.

Hamelin K, Bruant G, El-Shaarawi A, Hill S, Edge TA, Fairbrother JM, Harel J, Maynard C, Masson L, Brousseau R (2007). Occurrence of virulence and antimicrobial resistance genes in Escherichia coli from different aquatic ecosystems within the St. Clair River and Detroit River areas. Applied and Environmental Microbiology 73: 477-484.

Leclerc S, Boerlin P, Gyles CL, Dubreuil JD, Mourez M, Fairbrother JM, Harel J (2007). Paa, originally identified in attaching and effacing E. coli, is also associated with enterotoxigenic E. coli. Research in Microbiology 158: 97–104.

Hamelin K, Bruant G, El-Shaarawi A, Hill S, Edge TA, Bekal S, Fairbrother JM, Harel J, Maynard C, Masson L, Brousseau R (2006). A virulence and antimicrobial resistance DNA microarray detects a high frequency of virulence genes in Escherichia coli from Great Lakes recreational waters. Applied and Environmental Microbiology 72: 4200-4206.

Bouhet S, Le Dorze E, Peres S, Fairbrother JM, Oswald IP (2006). Mycotoxin fumonisin B1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies. Food and Chemical Toxicology 44: 1768-1773.

Cardinal F, D’Allaire S and Fairbrother JM (2006). Feed composition in herds with or without postweaning Escherichia coli diarrhea in early-weaned piglets. Journal of Swine Health and Production 14:10-17.

Girard F, Batisson I, Martinez G, Breton C, Harel J, Fairbrother JM (2006). Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections. FEMS Immunology and Medical Microbiology 46: 340-350.

Girard F, Oswald I, Taranu I, Hélie P, Appleyard G, Harel J, Fairbrother JM (2005). Host Immune Status Influences the Development of Attaching and Effacing Lesions in Weaned Pigs. Infection and Immunity 73: 5514-5523.

Girard F, Batisson I, Frankel G, Harel J, Fairbrother JM (2005). Interaction of Enteropathogenic and Shiga-Toxin Producing Escherichia coli with Porcine Intestinal Mucosa: Role of Intimin and Tir in Adherence. Infection and Immunity 73: 6005-6016.

Calinescu C, Mulhbacher J, Nadeau E, Fairbrother JM, Mateescu MA (2005). Carboxymethyl high amylase starch (CM-HAS) as excipient for Escherichia coli oral formulations. European Journal of Pharmaceutics and Biopharmaceutics 60: 53-60.

Oswald IP, Desautels C, Laffitte J, Fournout S, Péres SY, Odin M, Le Bars P, Le Bars J, Fairbrother JM (2003). Mycotoxin fumonisin B1 increases intestinal colonization by pathogenic Escherichia coli in pigs. Applied Environmental Microbiology 69: 5870-5874.

Batisson I, Guimond MP, Girard F, An H, Zhu C, Oswald E, Fairbrother JM, Jacques M, Harel J (2003). Characterization of the novel factor paa involved in the early steps of the adhesion mechanism of attaching and effacing Escherichia coli. Infection and Immunity 71: 4516–4525.

Bekal S, Brousseau R, Masson L, Préfontaine G, Fairbrother JM, Harel J (2003). Rapid identification of Escherichia coli pathotypes by virulence gene detection with DNA microarrays. Journal of Clinical Microbiology 41: 2113-25.

Dezfulian H, Batisson I, Fairbrother JM, Lau PCK, Nassar A, Szatmari G,Harel J (2003). Presence and characterization of extraintestinal pathogenic Escherichia coli virulence genes in F165-positive Escherichia coli strains isolated from diseased calves and pigs. Journal of Clinical Microbiology 41: 1375-1385.

Mellata M, Dho-Moulin M, Dozois CM, Curtiss III R, Brown PK, Arné P, Brée A, Desautels C, Fairbrother JM (2003). Role of virulence factors in resistance of avian pathogenic Escherichia coli to serum and in pathogenicity. Infection and Immunity 71: 536-540.

Mellata M, Dho-Moulin M, Dozois CM, Curtiss III R, Lehoux B, Fairbrother JM (2003). Role of avian pathogenic Escherichia coli virulence factors in bacterial interaction with chicken heterophils and macrophages. Infection and Immunity 71: 494-503.

 242-252.

Chapitres de livres

Fairbrother JM (2010). Colibacillosis. In Diseases of Swine. Zimmerman J, Karriker L, Ramirez A, Schwartz K, Stevenson G (editors). Iowa State University Press. Ames, Iowa, USA. 10th edition. Chapter 7: Sous presse.

Fairbrother JM and Nadeau E (2010). Colibacillosis. In Infectious and Parasitic Diseases of Livestock. Lefèvre PC, Blancou J, Chermette R, Uilenberg G (editors). Commonwealth Agricultural Bureau – International (CABI). Sous presse.

Gyles CL and Fairbrother JM (2009). Escherichia coli. In Pathogenesis of Bacterial Infections in Animals. Gyles CL, Prescott JF, Songer JG, Thoen CO (editors). Wiley-Blackwell. Ames, Iowa, USA. 4th edition. Chapter 15: 267-308.

Revues professionnelles et spécialisées

Fairbrother JM (2008). Escherichia coli en ganado porcino (Escherichia coli in pigs). Continuing training for Spanish-speaking Veterinarians: Articles 1-4. Suis 50: 56-62; 51: 50-59; 52: 44-54; 53: 44-56.

Fairbrother JM and Nadeau E (2006). Escherichia coli: On-farm contamination of animals. Revue scientifique et technique de l’Office International des Epizooties 25(2): 555-569.

Fairbrother, JM, Nadeau E and Gyles CL (2005). Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Animal Health Research Reviews 6: 17-39.

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