Main Menu
Members
LABORATORY OF DR. MARIELA SEGURA
- Research team - Field of activities - Research themes - Achievements - Publications -
|
|
|
| Telephone : (450) 773-8521 / office 0080 or laboratory 8389 | |
| Fax : (450) 778-8108 | |
|
E-mail : This email address is being protected from spambots. You need JavaScript enabled to view it. |
|
|
|
|
|
Ph.D Students :
|
|
|
|
|
|
M.Sc Students :
|
|
|
|
|
· Study the cellular and molecular basis of innate and adaptive immunity to capsular and/or exo-polysaccharides of extracellular bacteria and the role of dendritic cells (DCs) in orchestrating these responses
|
|
Ø Group B Streptococcus (GBS) : a model for the study of encapsulated bacteria :
· Characterize the interactions between encapsulated GBS and DCs, with particular emphasis on the receptors involved in DC recognition of encapsulated GBS.
· Characterize the interactions of encapsulated GBS with Natural Killer (NK) cells.
· Evaluate the role of DCs in the generation of GBS CPS-specific immune responses by direct activation of B cells or by multiple cross-talks involving NK and T cells.
Ø Streptococcus suis : a toxic shock- and meningitis-induced pathogen :
· Study in vitro the inflammatory response induced by S. suis through activation of divers host phagocytic and non-phagocytic cells (macrophages, neutrophils, epithelial and endothelial cells) and the receptors involved in these interactions.
· Establish a mouse model for the in vivo study of S. suis induced systemic and central nervous system disorders. To use congenic inbred mouse strains to dissect the genetic pathways involved in host susceptibility to S. suis infection.
· Study the interaction of S. suis with DCs and the downstream effect on innate and adaptive immune responses by modulation of T cell responses.
Ø Sialic acid : a surface component that decorate bacterial exo-polysaccharides :
· Dissect the role of sialic acid in the interactions of extracellular bacteria with cells of the immune system.
|
|
|
|
Gottschalk, M., M. Segura, N. Fittipaldi and J. Xu. Novel aspects on the emerging human pathogen: Streptococcus suis. Clinical Microbiology Newsletter. Cédulé pour publication mai 2010. Invited review.
Gottschalk, M. J. Xu, C. Calzas, M. Segura. 2010. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiology 5: 371-391. Invited review.
Gottschalk, M., and M. Segura. Streptococcus suis: infection en el hombre. SUIS. In press, 2009. Invited review.
Segura, M. Streptococcus suis: an emerging human threat. Invited Editorial Perspective. Journal of Infectious Diseases 199:4-6, 2009.
Segura, M., C. Matte, N. Thawani, Z. Su, and M. Stevenson. Modulation of malaria-induced immunopathology by concurrent nematode infection. International Journal for Parasitology. Revised version submitted, 2009.
Vanier, G., N. Fittipaldi, J. D. Slater, M. C. Domínguez, A. N. Rycroft, M. Segura, D. J. Maskell, and M. Gottschalk. New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells. Microbial Pathogenesis 46:13-20, 2009.
Vanier, G., M. Segura, M. P. Lecours, D. Grenier, and M. Gottschalk. Porcine brain microvascular endothelial cell-derived interleukin-8 is first induced and then degraded by Streptococcus suis. Microbial Pathogenesis 46:135-143, 2009.
Domínguez, M. C., M. Segura, D. Radzioch, S. Rivest, and M. Gottschalk. Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection. Infection and Immunity 76:3901-3910, 2008.
Han, Z., C. Ye, M. Segura, M. Gottschalk and J. Xu. Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome. Clinical and Experimental Immunology 153:385-391, 2008.
Segura, M., C. Matte, N. Thawani, Z. Su, and M. Stevenson. Modulation of malaria-induced immunopathology by concurrent nematode infection. J. Infect. Dis. Submitted, 2008.
Vanier, G., T. Sekizaki, M. C. Domínguez, M. Esgleas, M. Osaki, D. Takamatsu, M. Segura, and M. Gottschalk. Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins. Veterinary Microbiology 127:417-424, 2008.
Segura, M., R. Ing, Z. Su, N. Tawani, and M. Stevenson. Effector functions of macrophages in Plasmodium parasite infections. In: Protozoans in Macrophages. E. Denkers and R. Gazzinelli (Eds). Landes Bioscience, Austin, TX, USA. 2007, pp. 160-172. http://www.eurekah.com/chapter/3043 ISBN: 978-1-58706-150-9.
Gottschalk, M., M. Segura, and J. Xu. Porcine Streptococcus suis strains as a potential source of infections in humans: The Chinese experience and the situation in North America. Animal Health Research Reviews 8:29-45, 2007.
Segura, M., R. Ing, Z. Su, N. Tawani, and M. Stevenson. Effector functions of macrophages in Plasmodium parasite infections. In: Protozoans in Macrophages. E. Denkers and R. Gazzinelli (Eds). Landes Bioscience, Austin, TX, USA. ISBN: 978-1-58706-150-9; pp. 160-172, 2007.
Vanier, G., T. Sekizaki, M. C. Domínguez-Punaro, M. Esgleas, M. Osaki, D. Takamatsu, M. Segura, and M. Gottschalk. Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins. Vet. Microbiol. PMID: 17954016, 2007.
Dominguez-Punaro, M. C., M. Segura, M. Plante, S. Lacouture, S. Rivest, and M. Gottschalk. Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J. Immunol. 179:1842-1854, 2007.
Segura, M., Z. Su, C. Piccirillo, and M. Stevenson. Impairment of dendritic cell functions by excretory-secretory products: A potential mechanism for nematode-induced immunosuppression. Eur. J. Immunol. 37:1887-1904, 2007.
Vanier, G., M. Segura, and M. Gottschalk. Characterization of the invasion of porcine endothelial cells by Streptococcus suis serotype 2. Can. J. Vet. Res. 71:81-89, 2007.
Graveline, R., M. Segura, D. Radzioch, and M. Gottschalk. TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness. Int. Immunol. 19:375-389, 2007.
Gottschalk, M., and M. Segura. Lessons from China’s Streptococcus suis outbreak: The risk for humans. Pig Health and Welfare Featured Articles. http://www.thepigsite.com/articles. July 2007.
Gottschalk, M., and M. Segura. Streptococcus suis update and lessons learned from China’s outbreak: risk for humans. Proceedings of 38th Annual Meeting of the American Association of Swine Veterinarians, Orlando, Florida, 3-6 March. p. 377-380, 2007. Book.
Chabot-Roy, G., P. Willson, M. Segura, S. Lacouture, and M. Gottschalk. Phagocytosis and killing of Streptococcus suis by porcine neutrophils. Microb. Pathog. 41:21-32, 2006.
Ye, C., X. Zhu, H. Jing, H. Du, M. Segura, H. Zheng, B. Kan, L. Wang, X. Bai, Y. Zhou, Z. Cui, S. Zhang, D. Jin, N. Sun, X. Luo, J. Zhang, Z. Gong, X. Wang, L. Wang, H. Sun, Z. Li, Q. Sun, H. Liu, B. Dong, C. Ke, H. Yuan, H. Wang, K. Tian, Y. Wang, M. Gottschalk, J. Xu. Streptococcus suis sequence type 7 outbreak, Sichuan, China. J. Emerg. Infect. Dis. 12:1203-1208, 2006.
Segura, M., G. Vanier, S. Lacouture, M. Olivier, M. Gottschalk. Pro-inflammatory cytokine and chemokine modulation by Streptococcus suis serotype 2 in a porcine whole blood culture system. FEMS Immunol. Med. Microbiol. 47:92-106, 2006.
Su, Z., M. Segura, and M. Stevenson. Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection. Infect. Immun. 74:2138-2144, 2006.
Ing, R., M. Segura, N. Thawani, M. Tam, and M. Stevenson. Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation and antigen presentation. J. Immunol. 176:441-450, 2006.
Gottschalk, M. and M. Segura. The pathogenesis of the infection caused by Streptococcus suis serotype 2, an important swine and human pathogen. Proceedings of the Strangles, a Havemeyer Foundation Workshop, Christ Church, Barbados, 16-19 November. p. 275-278, 2006. Book.
Gottschalk, M., and M. Segura. Lessons learned from China’s Streptococcus suis outbreak: risk for humans. Proceedings of the Annual Meeting of the Western Canadian Association of Swine practitioners, Saskatoon, Canada, 12-14 October. p. 32, 2006. Book.
Gottschalk, M., and M. Segura. Immune response to Streptococcus suis infection: sometimes may help, sometimes may harm. Proceedings of the 36th Annual Meeting of the American Association of Swine Veterinarians, Toronto, Canada, 5-8 March. p. 479-486, 2005. Book.
Su, Z., M. Segura, K. Morgan, J. Loredo-Osti, and M. Stevenson. Impairment of protective immunity to blood-stage malaria by concurrent nematode infection. Infect. Immun. 73:3531-3539, 2005.