Membres
LABORATOIRE DE RECHERCHE SUR ACTINOBACILLUS PLEUROPNEUMONIAE
- L'équipe de recherche - Secteur d'activités - Thèmes de recherche - Réalisations - Publications -
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Téléphone : (450) 773-8521 bureau 8348 ou laboratoire 8272 |
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Télécopieur : (450) 778-8108 |
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Agente de recherche :
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Stagiaire posdoctoral :
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Étudiante de 3e cycle :
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Étudiantes de 2e cycle :
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- Identification et caractérisation des facteurs de virulence d’A. pleuropneumoniae
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Étude moléculaire des facteurs de virulence d'Actinobacillus pleuropneumoniae impliqués dans la colonisation des voies respiratoires
- Rôle des lipopolysaccharides (LPS) dans l’adhérence bactérienne
- Caractérisation et mutagénèse des gènes impliqués dans la formation de biofilm
Étude des gènes d’Actinobacillus pleuropneumoniae exprimés in vivo
- Profil transcriptomique à l’aide de biopuces à ADN
- Développement d'un vaccin mucosal sous-unitaire
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- Modèles in vitro pour l'étude de l'adhérence bactérienne à des cellules des voies respiratoires du porc
- Premières études de génomique comparative et de profil de transcription chez A.pleuropneumoniae
- Développement de modèles en microplaque et en chambre de flux pour l’étude des biofilms
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PUBLICATIONS (6 dernières années - liste partielle)
Jacques, M., V. Aragon, and Y.D.N. Tremblay. 2010. Biofilm formation in bacterial pathogens of veterinary importance. Animal Health Research Reviews (sous presse).
Ster, C., F. Beaudoin, M.S. Diarra, M. Jacques, F. Malouin, P. Lacasse. 2010. Evaluation of some Staphylococcus aureus iron–regulated proteins as vaccine targets. Veterinary Immunology and Immunopathology 136:311-318.
Silversides, D.W., N. Music, M. Jacques, C.A. Gagnon, R. Webby. 2010. Investigation of the species origin of the St. Jude Porcine Lung epithelial cell line (SJPL) made available to researchers. Journal of Virology 84:5454-5455.
Deslandes, V., M. Denicourt, C. Girard, J. Harel, J.H.E. Nash, M. Jacques. 2010. Transcriptional profiling of Actinobacillus pleuropneumoniae during the acute phase of a natural infection in pigs. BMC Genomics 11:98.
Labrie, J., G. Pelletier-Jacques, V. Deslandes, M. Ramjeet, É. Auger, J.H.E. Nash, M. Jacques. 2010. Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae. Veterinary Research 41:3.
Lone, A.G., V. Deslandes, J.H.E. Nash, M. Jacques, J.I. MacInnes. 2009. malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid. BMC Microbiology 14:195.
Lone, A.G., V. Deslandes, J.H.E. Nash, M. Jacques, J.I. MacInnes. 2009. Modulation of gene expression in Actinobacillus pleuropneumoniaeexposed to bronchoalveolar fluid. PLoS ONE 4·(7):e6139. doi:10.1371/journal.pone.0006139.
Gouré, J., W.A. Findlay, V. Deslandes, A. Bouevitch, S.J. Foote, J.I. MacInnes, J.W. Coulton, J.H.·Nash, M. Jacques. 2009. Microarray–based comparative genomic profiling of reference strains and selected Canadian field isolates of Actinobacillus pleuropneumoniae. BMC·Genomics 10:88.
Bouchet, B., G. Vanier, M. Jacques, É. Auger, M. Gottschalk. 2009. Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: Limited role of LOS in apoptosis and pro–inflammatory cytokine release. Microbial Pathogenesis 46:108-13.
Auger, É., V. Deslandes, M. Ramjeet, I. Contreras, J.H. Nash, J. Harel, M. Gottschalk, M.·Oliver and·M. Jacques. 2009. Host–pathogen interaction of Actinobacillus pleuropneumoniae with porcine lung and tracheal epithelial cells. Infection and Immunity 77:1426-41.· Publication sélectionnée pour la section «·Journal Highlights·» de la revue Microbe de l’ASM (mai 2009).
Ramjeet, M., A.·D. Cox, M.·A. Hancock, M.·Mourez, J. Labrie, M.·Gottschalk and·M. Jacques. 2008. Mutation in the LPS outer core biosynthesis gene, galU, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of Actinobacillus pleuropneumoniaeserotype·1. Molecular Microbiology 70:221–235.
Ramjeet, M., V. Deslandes, J. Gouré, M. Jacques. 2008. Actinobacillus pleuropneumoniae vaccines: from bacterins to new insights into vaccination strategies. Animal Health Research Reviews 9:25–45.
Bouchet, B., G. Vanier, M. Jacques, M. Gottschalk. 2008. Interactions of Haemophilus parasuis and its LOS with porcine brain microvascular endothelial cells. Veterinary Research 39:42.
Chung, W.J., C. Ng–Thow–Hing, L.IL Budman, B.F. Gibbs, J. H.E. Nash, M. Jacques, and J.W.·Coulton. 2007. Outer membrane proteome of Actinobacillus pleuropneumoniae:LC-MS/MS analyses validate in silico predictions. Proteomics 7:1854–1865.
Deslandes, V., J.H.E. Nash, J. Harel, J.W. Coulton and M. Jacques. 2007. ·Transcriptional profiling of Actinobacillus pleuropneumoniae under iron–restricted conditions. BMC·Genomics 8:72.
Allard, M., H. Moisan, E. Brouillette, A.L. Gervais, M. Jacques, P. Lacasse, M.S. Diarra and F. Malouin. 2006. Transcriptional modulation of some Staphylococcus aureus iron–regulated genes during growth in vitro and in a tissue cage model in vivo. Microbes and Infection 8:1679–1690.
Lagacé, L. M. Jacques, A.A. Mafu, and D. Roy. 2006. Biofilm formation and biocides sensitivity of Pseudomonas marginalis isolated from a maple sap collection system. Journal of Food Protection 69:2411–2416.
Shakarji, L., L. G. Mikael, R. Srikumar, M. Kobisch, J. W. Coulton and M. Jacques. 2006. FhuA and HgbA, Outer Membrane Proteins of Actinobacillus pleuropneumoniae: Role as Virulence Determinants. Canadian Journal of Microbiology 52:391–396.
Lillie, B.N., J.D. Hammermueller, J.I. Macinnes, M. Jacques, M.A. Hayes. 2006. Porcine mannan–binding lectin A binds to Actinobacillus suis and Haemophilus parasuis. Developmental and Comparative Immunology 30:954–965.
Lagacé, L., M. Jacques, A. A. Mafu and D. Roy. 2006. Compositions of maple sap microflora and collection system biofilms evaluated by scanning electron microscopy and denaturing gradient gel electrophoresis. International Journal of Food Microbiology 109:9–18.
Li, Y., G. Martinez, M. Gottschalk, S. Lacouture, P. Willson, J.D. Dubreuil, M. Jacques and J. Harel. 2005. Identification of a Surface Protein of Streptococcus suis and Evaluation of its Immunogenic and Protective Capacity in Pigs. Infection and Immunity 74:305–312.
Jacques, M., J. Labrie, F. St. Michael, A. D. Cox, A.-M. Paradis, C.P. Dick, C. Klopfenstein, A. Broes, N. Fittipaldi and M. Gottschalk. 2005. Isolation of an Atypical Strain of Actinobacillus pleuropneumoniae Serotype 1 With a Truncated Lipopolysaccharide Outer Core and No O–Antigen. Journal of Clinical Microbiology. 43:3522–3525.
Vanier, G., A. Szczotka, P. Friedl, S. Lacouture, M. Jacques and M. Gottschalk. 2005. Haemophilus parasuis invades porcine brain microvascular endothelial cells. Microbiology 152:135–142.
Ramjeet, M., V. Deslandes, F. St. Michael, A. D. Cox, M. Kobisch, M. Gottschalk and M. Jacques. 2005. Truncation of the LPS outer core affects susceptibility to antimicrobial peptides and virulence of Actinobacillus pleuropneumoniae serotype 1. Journal of Biological Chemistry 280:39104–39114.